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Endocannabinoid-lipase

Biology of endocannabinoid synthesis system - ScienceDirect Endocannabinoids (endogenous ligands of cannabinoid receptors) exert diverse physiological and pathophysiological functions in animal tissues. N-Arach… Helmholtz Alliance ICEMED Imaging and Curing Environmental An endocannabinoid lipase offering a new target for weight loss without mood impairments? WOLFGANG LANGHANS, ETH Zürich GLP-1, an “old” peptide still good for surprises PETER JEZZARD, University of Oxford Localized measurements of oxygen extraction fraction in human brain

Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition Leiden Repository. Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition. Type: Article / Letter to e

21 Sep 2011 Endocannabinoid (eCB) signaling is tightly regulated by eCB abolished in mice lacking the 2-AG biosynthetic enzyme diacylglycerol lipase-α  29 Jan 2013 Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons. 30 Jul 2015 Endocannabinoids (eCB) are key regulators of excitatory/inhibitory neurotransmission at cannabinoid‐1‐receptor (CB1R)‐expressing axon  1 Dec 2018 Monoacylglycerol lipase (MGLL) is the primary degradative enzyme for To support clinical investigation of endocannabinoid modulation, we 

30 Jul 2015 Endocannabinoids (eCB) are key regulators of excitatory/inhibitory neurotransmission at cannabinoid‐1‐receptor (CB1R)‐expressing axon 

25 Jul 2007 Hydrolysis of Prostaglandin Glycerol Esters by the Endocannabinoid-Hydrolyzing Enzymes, Monoacylglycerol Lipase and Fatty Acid Amide  Pathway map. hsa04723, Retrograde endocannabinoid signaling 747, DAGLA; diacylglycerol lipase alpha [KO:K13806] [EC:3.1.1.-]. 221955, DAGLB  Converts monoacylglycerides to free fatty acids and glycerol (PubMed:12136125). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby 

Here, we describe the synthesis and characterization of CNS-active, covalent 1,2,3-triazole urea inhibitors of DAGLα and -β that, when paired with a structurally related control compound

Converts monoacylglycerides to free fatty acids and glycerol (PubMed:12136125). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby  acylglycerol lipase (MGLL) results in lipid overload in TAMs. Functionally, macrophage MGLL inhibits CB2 cannabinoid receptor-dependent tumor progression  7 Mar 2014 The neuromodulatory activities of the endocannabinoid (EC) system the MG lipase is responsible for the hydrolysis of 2-AG to arachidonic  24 Feb 2016 Evidence also suggests that dysregulation of the endocannabinoid In addition, monoacylglycerol lipase (MGL), the primary degradative  Metabolic Enzymes for Endocannabinoids and Endocannabinoid-Like